Key laws and policies
- Human Tissue Act (s.39A inserted by s.26 of Act No. 51 of 1989) (1983)
- National Health Act (December 31, 2003)
The South African government practices the precautionary principle by stating, "The risk attached to the use of the technique on humans carries the possibility of hormonal manipulation in the egg donor, multiple miscarriages in the birth mother, and severe developmental abnormalities in any resulting child. The potential harms outweigh the potential benefits, and until studies in animal systems reverse this circumstance, we recommend that the use of human nuclear transfer cloning to create a new life should be prohibited."
It is recommended that recommendations of the US National Bioethics Advisory Committee should regulate the donation of human embryos for stem cell research.
The following practices are prohibited by the National Health Act:
- Inheritable genetic modification
- Reproductive cloning
Permitted and regulated practices
South Africa does not regulate preimplantation genetic diagnosis explicitly by legislation or professional guidelines. However, the Medical Research Council of South Africa states that selecting sex is unethical if done for non-medical purposes.
The National Health Act permits research cloning.
Surrogacy is covered by guidelines, implying the absence of national law. 
- American Society for Reproductive Medicine, "IFFS Surveillance 07," Fertility and Sterility (Vol. 87. No. 4, Suppl. 1, April 2007)
- Singapore Bioethics Advisory Committee, “Donation Of Human Eggs For Research: A Consultation Paper,” 7 November 2007